Transdermal Solution Delivery Systems

Transdermal delivery systems focus on overcoming the skin barrier for more practical applications of pharmaceutical and cosmetic products. Although the cosmeceutical industry has made substantial progress in developing and incorporating new and effective actives in their products, the barrier function of the skin remains a limiting factor in the penetration and absorption of these actives.

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Physical forces, including electrical voltage (iontophoresis, electroporation), ultrasound (sonophoresis), microneedles, thermal ablation, magnetophoretic, photomechanical waves, and electron beam irradiation, are effectively used to overcome the skin barrier.

Device-based approaches to increase skin permeability or provide a driving force for transport appear to be broadly effective at increasing the transdermal delivery of macromolecules. Physical mechanisms generally create micron-scale pores in the SC, enabling the transport of large molecules.

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